There are some excellent plop base industries for specialist cities such as lumber mills and mining and I love these, BUT, the no freight is a major draw-back. I would love to have a couple of these or more major theme large (and supporting) industries that would grow in fairly new/small city to build from. I can see where such industries would need special demand adjustments to make them grow just after the ag phase and maybe thats not feasible. I guess "I want my cake and eat it too"
Doesn't hurt to ask.